S-8666

S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S- (-) - and R- (+) -isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S- (-) -isomer, while the R- (+) -isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees) [1][2].

Product Specifications

CAS Number

[103968-87-2]

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

O=C(C1OC2=C(C1)C=C(S(=O)(N(C)C)=O)C(Cl)=C2Cl)O

Molecular Formula

C11H11Cl2NO5S

Molecular Weight

340.18

References & Citations

[1]Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20 (3) :350-5. |[2]Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43 (4) :389-98. doi: 10.1254/jjp.43.389. Yonetani Y, et al. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43 (4) :389-98. doi: 10.1254/jjp.43.389.