AMG 7905 (TFA)
AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2].
Product Specifications
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Purity
99.06
Solubility
DMSO : 100 mg/mL
Smiles
OC(C(F)(F)F)=O.FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F
Molecular Formula
C27H25F6N5O2S
Molecular Weight
597.58
References & Citations
[1]Garami A, et al. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf) . 2018 Jul;223 (3) :e13038.|[2]Lehto SG, et al. Antihyperalgesic effects of (R, E) -N- (2-hydroxy-2,3-dihydro-1H-inden-4-yl) -3- (2- (piperidin-1-yl) -4- (trifluoromethyl) phenyl) -acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008 Jul;326 (1) :218-29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP303798 20 µg
Dystrobrevin beta (DTNB) (NM_183361) Human Recombinant Protein
Sign In for Pricing
View Details 
![SDHB Mouse Monoclonal Antibody [Clone ID: OTI2A3]](https://cdn.genprice.uk/products/937/68dd18b9061270361e90827f/imageurl/cf808201.webp)
