AMG 7905 (TFA)

AMG 7905 TFA is a hypothermia-inducing transient receptor potential vanilloid type 1 (TRPV1) antagonist. AMG 7905 TFA potentiates TRPV1 channels activation by protons and drives the reflectory inhibition of thermogenesis and tail-skin vasoconstriction, while potently blocking channel activation by capsaicin[1][2].

Product Specifications

UNSPSC

12352005

Target

TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Purity

99.06

Solubility

DMSO : 100 mg/mL

Smiles

OC(C(F)(F)F)=O.FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F

Molecular Formula

C27H25F6N5O2S

Molecular Weight

597.58

References & Citations

[1]Garami A, et al. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf) . 2018 Jul;223 (3) :e13038.|[2]Lehto SG, et al. Antihyperalgesic effects of (R, E) -N- (2-hydroxy-2,3-dihydro-1H-inden-4-yl) -3- (2- (piperidin-1-yl) -4- (trifluoromethyl) phenyl) -acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther. 2008 Jul;326 (1) :218-29.