Ageladine A (dihydrochloride)

Ageladine A dihydrochloride is an inhibitor of matrix metalloproteinase (MMP) isolated from the marine sponge Agelas nakamurai, possessing anti-angiogenic activity. Ageladine A dihydrochloride not only inhibits MMP-2 but also MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC50 values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. Additionally, Ageladine A dihydrochloride is a pH-sensitive membrane-permeable dye that emits fluorescence in the blue-green range upon UV excitation, featuring a maximum absorption peak at 370 nm. Furthermore, Ageladine A dihydrochloride serves as a reliable and stable fluorescent pH sensor for detecting changes in intracellular pH values[1][2].

Product Specifications

CAS Number

[2757574-06-2]

UNSPSC

12352005

Target

Fluorescent Dye; MMP

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

BrC1=C(Br)NC(C2=NC=CC3=C2N=C(N)N3)=C1.Cl.Cl

Molecular Formula

C10H9Br2Cl2N5

Molecular Weight

429.93

References & Citations

[1]Fujita M, et al. Ageladine A: An Antiangiogenic Matrixmetalloproteinase Inhibitor from the Marine Sponge Agelas N Akamurai[J]. Journal of the American Chemical Society, 2003, 125 (51) : 15700-15701.|[2]Bickmeyer U, et al. Ageladine A, a pyrrole–imidazole alkaloid from marine sponges, is a pH sensitive membrane permeable dye[J]. Biochemical and biophysical research communications, 2008, 373 (3) : 419-422.