ABT-255 (hydrochloride)
ABT-255 hydrochloride is an orally active anti-bacterial agent. ABT-255 hydrochloride exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin - or Ethambutol (HY-B0535) -resistant Mycobacterium tuberculosis. ABT-255 hydrochloride shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 hydrochloride can be used for the study of pulmonary tuberculosis[1].
Product Specifications
CAS Number
181141-52-6
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(O)C1=CC(C2CC2)=C3C(C)=C(C(F)=CN3C1=O)N4C[C@]([H])(CCCN5)[C@@]5([H])C4.Cl
Molecular Formula
C21H25ClFN3O3
Molecular Weight
421.89
References & Citations
[1]Oleksijew A, et al. In vivo efficacy of ABT-255 against drug-sensitive and -resistant Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Oct;42 (10) :2674-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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