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Hepoxilin A3

Hepoxilin A3 (HXA3) is a neutrophil chemo-attractant, synthesized by activating the PLA2-12-LOX pathway. Hepoxilin A3 can guide neutrophils to cross the epithelial barrier and migrate to the infection site (such as the alveolar cavity) . The level of Hepoxilin A3 increases synchronously with neutrophil infiltration in mouse models. Hepoxilin A3 can be used to study inflammatory diseases (such as pneumonia, cystic fibrosis) [1].

Product Specifications

CAS Number

[94161-11-2]

Product Name Alternative

HXA3

UNSPSC

12352005

Target

Others

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CCCCC/C=C\C[C@]1([H])O[C@@]1(/C=C/C(C/C=C\CCCC(O)=O)O)[H]

Molecular Formula

C20H32O4

Molecular Weight

336.47

References & Citations

[1]Tamang DL, et al. Hepoxilin A (3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15;189 (10) :4960-9.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-113500A/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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