Hepoxilin A3
Hepoxilin A3 (HXA3) is a neutrophil chemo-attractant, synthesized by activating the PLA2-12-LOX pathway. Hepoxilin A3 can guide neutrophils to cross the epithelial barrier and migrate to the infection site (such as the alveolar cavity) . The level of Hepoxilin A3 increases synchronously with neutrophil infiltration in mouse models. Hepoxilin A3 can be used to study inflammatory diseases (such as pneumonia, cystic fibrosis) [1].
Product Specifications
CAS Number
94161-11-2
Product Name Alternative
HXA3
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CCCCC/C=C\C[C@]1([H])O[C@@]1(/C=C/C(C/C=C\CCCC(O)=O)O)[H]
Molecular Formula
C20H32O4
Molecular Weight
336.47
References & Citations
[1]Tamang DL, et al. Hepoxilin A (3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15;189 (10) :4960-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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