Cyclic GMP (Standard)

Cyclic GMP (Standard) is the analytical standard of Cyclic GMP (HY-113469) . This product is intended for research and analytical applications. Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs) . Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].

Product Specifications

CAS Number

[7665-99-8]

UNSPSC

12352005

Target

Endogenous Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology; Cardiovascular Disease

Purity

99.54

Smiles

O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O

Molecular Formula

C10H12N5O7P

Molecular Weight

345.21

References & Citations

[1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339 (6121) :826-30.|[2]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503 (7477) :530-4.