Tetrahydrocorticosterone

Tetrahydrocorticosterone is a type of glucocorticoid with notable anti-inflammatory properties. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), acts by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a role in regulating the metabolism of carbohydrates, proteins, and fats[1][2].

Product Specifications

CAS Number

[68-42-8]

UNSPSC

12352211

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

97.02

Smiles

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@](CC[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]3O

Molecular Formula

C21H34O4

Molecular Weight

350.49

References & Citations

[1]McInnes KJ, et al. (May 2004) . 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. The Journal of Biological Chemistry. 279 (22) : 22908-12.|[2]Higashi T, et al. Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS. Steroids. 2007;72 (13) :865-874.