Tetrahydrodeoxycorticosterone
Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].
Product Specifications
CAS Number
567-03-3
Product Name Alternative
Tetrahydro-11-deoxycorticosterone
UNSPSC
12352211
Target
Endogenous Metabolite; GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2
Molecular Formula
C21H34O3
Molecular Weight
334.49
References & Citations
[1]Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300.|[2]Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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