Tetrahydrodeoxycorticosterone

Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2].

Product Specifications

CAS Number

[567-03-3]

Product Name Alternative

Tetrahydro-11-deoxycorticosterone

UNSPSC

12352211

Target

Endogenous Metabolite; GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2

Molecular Formula

C21H34O3

Molecular Weight

334.49

References & Citations

[1]Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300.|[2]Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.