Ap4A (tetraammonium)

Ap4A tetraammonium (P1, P4-Di- (adenosine-5') -tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis[1][2].

Product Specifications

CAS Number

[102783-36-8]

Product Name Alternative

P1, P4-Di- (adenosine-5') -tetraphosphate (tetraammonium)

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.98

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OP(OP(OC[C@H]4O[C@@H](N5C=NC6=C5N=CN=C6N)[C@H](O)[C@@H]4O)(O)=O)(O)=O)(O)=O)(O)=O.N.N.N.N

Molecular Formula

C20H40N14O19P4

Molecular Weight

904.51

References & Citations

[1]Yu J, et al. Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells. Nat Commun. 2019 Oct 11;10 (1) :4664.|[2]Vartanian A, et al. Ap4A induces apoptosis in human cultured cells. FEBS Lett. 1999 Jul 30;456 (1) :175-80.