3-Hydroxykynurenine-13C2,15N (hydrochloride)

3-Hydroxykynurenine-13C2,15N (3-Hydroxy-DL-kynurenine-13C2,15N) hydrochloride is the 13C and 15N labeled 3-Hydroxykynurenine hydrochloride (HY-113294) [1]. 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[2].

Product Specifications

Product Name Alternative

3-Hydroxy-DL-kynurenine-13C2,15N (hydrochloride)

UNSPSC

12352005

Target

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

98.74

Smiles

OC1=CC=CC(C(C[13CH]([15NH2])[13C](O)=O)=O)=C1N.[xHCl]

Molecular Formula

C8 13C2H12N 15NO4.xHCl

References & Citations

[1]S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70 (1) :299-307.