Estrone sulfate (sodium) (Standard)

Estrone sulfate (sodium) (Standard) is the analytical standard of Estrone sulfate (sodium) . This product is intended for research and analytical applications. Estrone sulfate, a biologically inactive form of estrogen, is a major circulating plasma estrogen that is converted into the biologically active estrogen, estrone (E1) by steroid sulfatase (STS) . Estrone sulfate can be used for the research of breast cancer[1][2].

Product Specifications

CAS Number

[438-67-5]

UNSPSC

12352100

Target

Endogenous Metabolite; Estrogen Receptor/ERR; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=C(C=CC(OS(=O)(O[Na])=O)=C4)[C@@]3([H])CC1)C2=O

Molecular Formula

C18H21NaO5S

Molecular Weight

372.41

References & Citations

[1]Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163 (4) :1329-1339. |[2]Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53 (2) :298-303.|[3]Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6) . Front Pharmacol. 2018;9:941. Published 2018 Aug 21.