Guanosine triphosphate-13C10,15N5 (tetraammonium)

Guanosine triphosphate-13C10,15N5 (tetraammonium) is the 13C and 15N labeled Guanosine triphosphate tetraammonium[1]. Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19[2].

Product Specifications

Product Name Alternative

GTP-13C10,15N5 (tetraammonium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog; SARS-CoV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

O[13C@H]1[13C@H]([13C@@H](O[13C@@H]1[13CH2]OP(OP(OP(O)(O)=O)(O)=O)(O)=O)[15N]2[13C]([15N]=[13C]([15NH]3)[15NH2])=[13C]([15N]=[13CH]2)[13C]3=O)O.N.N.N.N

Molecular Formula

13C10H28N4 15N5O14P3

Molecular Weight

606.20

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Abdo A Elfiky, et al. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477.