Desmosterol (Standard)

Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].

Product Specifications

CAS Number

[313-04-2]

UNSPSC

12352211

Target

Endogenous Metabolite; Fatty Acid Synthase (FASN) ; Interleukin Related; LXR; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; Reference Standards

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Smiles

C/C(C)=C\CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C27H44O

Molecular Weight

384.64

References & Citations

[1]Clark RM, et al. Desmosterol in human milk. Lipids. 1983;18 (3) :264-266.|[2]Zhang X, et al. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proc Natl Acad Sci U S A. 2021 Nov 23;118 (47) :e2107682118.|[3]Muse ED, et al. Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. Proc Natl Acad Sci U S A. 2018 May 15;115 (20) :E4680-E4689.