17-Hydroxypregnenolone sulfate (sodium)

17-Hydroxypregnenolone sulfate sodium is a key brain-penetrant intermediate in adrenal and gonadal steroidogenesis. 17-Hydroxypregnenolone sulfate sodium acts as a precursor in the biosynthesis of steroid hormones (e.g., glucocorticoids, sex hormones) . 17-Hydroxypregnenolone sulfate sodium is promising for research of adrenal function development and neurosteroid-related diseases (e.g., cognitive impairment, neurodegenerative diseases) [1][2][3].

Product Specifications

CAS Number

[1106675-81-3]

UNSPSC

12352211

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Neurological Disease

Purity

99.64

Smiles

C[C@@]12[C@](CC[C@]2(O)C(C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)OS(=O)(O[Na])=O)=CC3)C

Molecular Formula

C21H31NaO6S

Molecular Weight

434.52

References & Citations

[1]Shimozawa K, et al. Age-related changes in serum 17-hydroxypregnenolone and 17-hydroxypregnenolone sulfate concentrations in human infancy and childhood. Endocrinol Jpn. 1988 Apr;35 (2) :189-95.|[2]Hu D, et al. Biosynthesis of triterpenoid natural products[J]. Comprehensive Natural Products III, 2020: 577-612.|[3]Qaiser MZ, et al. Uptake and metabolism of sulphated steroids by the blood-brain barrier in the adult male rat. J Neurochem. 2017 Sep;142 (5) :672-685.