3-Hydroxyisobutyric acid (Standard)

3-Hydroxyisobutyric acid (Standard) is the analytical standard of 3-Hydroxyisobutyric acid. This product is intended for research and analytical applications. 3-Hydroxyisobutyric acid is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.

Product Specifications

CAS Number

[2068-83-9]

UNSPSC

12352100

Target

ATP Synthase; Endogenous Metabolite; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=C(O)C(C)CO

Molecular Formula

C4H8O3

Molecular Weight

104.10

References & Citations

[1]Podebrad F, et al. Stereodifferentiation of 3-hydroxyisobutyric- and 3-aminoisobutyric acid in human urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry. Clin Chim Acta. 2000 Feb 25;292 (1-2) :93-105.|[2]Viegas CM, et al. Evidence that 3-hydroxyisobutyric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats. Int J Dev Neurosci. 2008 May-Jun;26 (3-4) :293-9.|[3]Mardinoglu A, et al. Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes. EBioMedicine. 2018 Jan;27:151-155.|[4]Landaas S. Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis. Clin Chim Acta. 1975 Oct 15;64 (2) :143-54.