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Guanosine 5'-diphosphate (disodium salt) (Standard)

Guanosine 5'-diphosphate (disodium salt) (Standard) is the analytical standard of Guanosine 5'-diphosphate (disodium salt) . This product is intended for research and analytical applications. Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR) . Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400) -ferroportin interaction and modulates the interleukin-6 (IL-6) /stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI) [1][2][3][4][5].

Product Specifications

CAS Number

[7415-69-2]

UNSPSC

12352100

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Hepcidin; Potassium Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(O)([O-])=O)([O-])=O.[2Na+]

Molecular Formula

C10H13N5Na2O11P2

Molecular Weight

487.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.|[2]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. |[3]Ciruela F. Guanosine behind the scene. J Neurochem. 2013 Aug;126 (4) :425-7.|[4]Raj GV, et al. Guanosine phosphate binding protein coupled receptors in prostate cancer: a review. J Urol. 2002 Mar;167 (3) :1458-63.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

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