N1-Acetylspermidine-d3 (hydrochloride)

N1-Acetylspermidine-d3 hydrochloride is the deuterium labeled N1-Acetylspermidine hydrochloride (HY-113056A) . N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO) . N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research[1][2][3][4][5].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

NCCCCNCCCNC(C([2H])([2H])[2H])=O.Cl.Cl

Molecular Formula

C9H20D3Cl2N3O

Molecular Weight

263.22

References & Citations

[1]Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1, N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44 (18) :7079-84.|[2]Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.|[3]Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44 (2) :845-7.|[4]Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2 (10) :pgad306.|[5]Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29 (2) :423-8.