5-Methyltetrahydrofolic acid-13C6

5-Methyltetrahydrofolic acid-13C6 (5-Methyl THF-13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases[1][2].

Product Specifications

CAS Number

[212248-92-5]

Product Name Alternative

5-Methyl THF-13C6; 5-MTHF-13C6

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

CN1C2=C(NC(N)=NC2=O)NCC1CN[13C]3=[13CH][13CH]=[13C]([13CH]=[13CH]3)C(N[C@H](C(O)=O)CCC(O)=O)=O

Molecular Formula

C14 13C6H25N7O6

Molecular Weight

465.41

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Wright AJ, et al. Comparison of (6 S) -5-methyltetrahydrofolic acid v. folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults. Br J Nutr. 2010 Mar;103 (5) :724-9.|[3]Ronco, et al. "5-methyltetrahydrofolic acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells." Nutrition, Metabolism and Cardiovascular Diseases 17.3 (2007) : 188-194.