5-Methyltetrahydrofolic acid

5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases[1][2].

Product Specifications

CAS Number

[134-35-0]

Product Name Alternative

5-Methyl THF; 5-MTHF

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Purity

99.77

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C)C3=C(NC(N)=NC3=O)NC2)C=C1)=O

Molecular Formula

C20H25N7O6

Molecular Weight

459.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Wright AJ, et al. Comparison of (6 S) -5-methyltetrahydrofolic acid v. folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults. Br J Nutr. 2010 Mar;103 (5) :724-9.|[2]Ronco, et al. "5-methyltetrahydrofolic acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells." Nutrition, Metabolism and Cardiovascular Diseases 17.3 (2007) : 188-194.