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(17R,18S) -Epoxyeicosatetraenoic acid

Selected Variant

HY-113040A

Size: 25 μg (314.02 μM x 250 μL in Ethanol)

(17R,18S) -Epoxyeicosatetraenoic acid (17 (R),18 (S) -EETeTr) is a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid. (17R,18S) -Epoxyeicosatetraenoic acid shows exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca2+ overload. (17R,18S) -Epoxyeicosatetraenoic acid has the potential for the research of antiarrhythmic agent[1][2].

Product Specifications

CAS Number

725246-18-4

Product Name Alternative

17 (R),18 (S) -EETeTr

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Concentration

314.02 μM * 250 μL in Ethanol

Purity

93.0

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C[C@@H]1[C@@H](O1)CC)=O

Molecular Formula

C20H30O3

Molecular Weight

318.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]alck JR, et al. 17 (R),18 (S) -epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues. J Med Chem. 2011 Jun 23;54 (12) :4109-18.|[2]Adebesin AM, et al. Development of Robust 17 (R),18 (S) -Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents. J Med Chem. 2019 Nov 27;62 (22) :10124-10143.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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