Farnesyl pyrophosphate-d6

Farnesyl pyrophosphate-d6 (Farnesyl diphosphate-d6) is a deuterium labeled Farnesyl pyrophosphate (HY-113037B) . Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.

Product Specifications

CAS Number

[895550-58-0]

Product Name Alternative

Farnesyl diphosphate-d6

UNSPSC

12352211

Target

Calcium Channel; Endogenous Metabolite; Isotope-Labeled Compounds; TRP Channel

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Smiles

O=P(O)(O)OP(OC/C=C(C)/CC/C=C(C)/CC/C=C(C([2H])([2H])[2H])/C([2H])([2H])[2H])(O)=O

Molecular Formula

C15H22D6O7P2

Molecular Weight

388.36

References & Citations

[1]Waller DD, et al. Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers. Crit Rev Biochem Mol Biol. 2019 Feb;54 (1) :41-60.