α-D-Glucose 1,6-bisphosphate
α-D-Glucose 1,6-bisphosphate is a bis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism[1]. It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate[2]. It is also a cofactor for the bacterial enzyme phosphopentomutase[3][4].
Product Specifications
CAS Number
10139-18-1
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=P(O)(OC[C@H]1O[C@H](OP(O)(O)=O)[C@@H]([C@H]([C@@H]1O)O)O)O
Molecular Formula
C6H14O12P2
Molecular Weight
340.12
References & Citations
[1]Beitner, R. Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate. Int. J. Biochem. 22 (6), 553-557 (1990) .|[2]Maliekal, P., Sokolova, T., Vertommen, D., et al. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the α-D-phosphohexomutase family. The Journal of Biological Chemisty 282 (44), 31844-31851 (2007) .|[3]Moustafa, H.M.A., Zaghloul, T.I., and Zhang, Y.-H.P. A simple assay for determining activities of phosphopentomutase from a hyperthermophilic bacterium Thermotoga maritima. Anal. Biochem. 501, 75-81 (2016) .|[4]Panosian, T.D., Nannemann, D.P., Watkins, G.R., et al. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. The Journal of Biological Chemisty 286 (10), 8043-8054 (2011) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog