α-D-Glucose 1,6-bisphosphate

α-D-Glucose 1,6-bisphosphate is a bis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism[1]. It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate[2]. It is also a cofactor for the bacterial enzyme phosphopentomutase[3][4].

Product Specifications

CAS Number

[10139-18-1]

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=P(O)(OC[C@H]1O[C@H](OP(O)(O)=O)[C@@H]([C@H]([C@@H]1O)O)O)O

Molecular Formula

C6H14O12P2

Molecular Weight

340.12

References & Citations

[1]Beitner, R. Regulation of carbohydrate metabolism by glucose 1,6-bisphosphate in extrahepatic tissues; comparison with fructose 2,6-bisphosphate. Int. J. Biochem. 22 (6), 553-557 (1990) .|[2]Maliekal, P., Sokolova, T., Vertommen, D., et al. Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the α-D-phosphohexomutase family. The Journal of Biological Chemisty 282 (44), 31844-31851 (2007) .|[3]Moustafa, H.M.A., Zaghloul, T.I., and Zhang, Y.-H.P. A simple assay for determining activities of phosphopentomutase from a hyperthermophilic bacterium Thermotoga maritima. Anal. Biochem. 501, 75-81 (2016) .|[4]Panosian, T.D., Nannemann, D.P., Watkins, G.R., et al. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. The Journal of Biological Chemisty 286 (10), 8043-8054 (2011) .