CMP-SiaNAz (sodium)

CMP-SiaNAz (CMP-NeuNAz) sodium is a sialic acid nucleotide sugar derivative. CMP-SiaNAz sodium is integrated into the glycosidic chain through the action of STs in the Golgi apparatus, forming SiaNAz substances. CMP-SiaNAz sodium can serve as a substrate for bacterial-derived sialic acid transferases and is used for chemical enzymatic labeling and imaging of cell surface glycosides[1][2].

Product Specifications

Product Name Alternative

CMP-NeuNAz (sodium)

UNSPSC

12352005

Target

Sialyltransferase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O[C@@]3(C(O[Na])=O)C[C@H](O)[C@@H](NC(CN=[N+]=[N-])=O)[C@H]([C@H](O)[C@H](O)CO)O3)(O[Na])=O)O2)=NC1=O

Molecular Formula

C20H28N7Na2O16P

Molecular Weight

699.43

References & Citations

[1]Hong S, et al. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification. Nat Commun. 2019 Apr 17;10 (1) :1799.|[2]Martinez-Duncker I, et al. Towards in vivo imaging of cancer sialylation. Int J Mol Imaging. 2011;2011:283497.