YW3-56 (hydrochloride)

YW3-56 (hydrochloride) is a PAD inhibitor. YW3-56 (hydrochloride) activates p53 target genes. YW3-56 (hydrochloride) activates ATF and blocks autophagy flux. YW3-56 induces ER stress through the PERK-eIF2α-ATF4 signaling cascade and inhibits the mTOR signaling. YW3-56 (hydrochloride) inhibits triple-negative breast cancer[1].

Product Specifications

CAS Number

[2309756-20-3]

UNSPSC

12352005

Target

Autophagy; MDM-2/p53; mTOR; PERK; Protein Arginine Deiminase

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C(C1=CC=C2C=C(N(C)C)C=CC2=C1)N[C@H](C(NCC3=CC=CC=C3)=O)CCCNC(CCl)=N.Cl

Molecular Formula

C27H33Cl2N5O2

Molecular Weight

530.49

References & Citations

[1]Wang S, et al. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015 Apr;14 (4) :877-88.