C- (2'FdAMP-2'FdIMP)
C- (2'FdAMP-2'FdIMP) (Compound 52), a derivative of cAIMP , is a cyclic dinucleotide (CDN). c- (2'FdAMP-2'FdIMP) is a STING activator and significantly induce STING-dependent IRF and NF-κB pathway signaling. c- (2'FdAMP-2'FdIMP) can be used for STING-based immunotherapy, such as cancers and infectious diseases research[1].
Product Specifications
CAS Number
1951464-78-0
UNSPSC
12352005
Target
Drug Derivative; IFNAR; Interleukin Related; NF-κB; STING
Related Pathways
Immunology/Inflammation; NF-κB; Others
Field of Research
Cancer; Infection
Smiles
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](OP4(O)=O)[C@@H](COP(O)(O[C@H]5[C@@H](F)[C@H](N(C=N6)C7=C6C(O)=NC=N7)O[C@@H]5CO4)=O)O3
Molecular Formula
C20H21F2N9O11P2
Molecular Weight
663.38
References & Citations
[1]Lioux T, et al. Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING) . J Med Chem. 2016 Nov 23;59 (22) :10253-10267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1
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