C- (2'FdAMP-2'FdIMP)

C- (2'FdAMP-2'FdIMP) (Compound 52), a derivative of cAIMP (HY-134375), is a cyclic dinucleotide (CDN) . c- (2'FdAMP-2'FdIMP) is a STING activator and significantly induce STING-dependent IRF and NF-κB pathway signaling. c- (2'FdAMP-2'FdIMP) can be used for STING-based immunotherapy, such as cancers and infectious diseases research[1].

Product Specifications

CAS Number

[1951464-78-0]

UNSPSC

12352005

Target

Drug Derivative; IFNAR; Interleukin Related; NF-κB; STING

Related Pathways

Immunology/Inflammation; NF-κB; Others

Field of Research

Cancer; Infection

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](F)[C@H](OP4(O)=O)[C@@H](COP(O)(O[C@H]5[C@@H](F)[C@H](N(C=N6)C7=C6C(O)=NC=N7)O[C@@H]5CO4)=O)O3

Molecular Formula

C20H21F2N9O11P2

Molecular Weight

663.38

References & Citations

[1]Lioux T, et al. Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING) . J Med Chem. 2016 Nov 23;59 (22) :10253-10267.