8-Oxo-dGTP
8-Oxo-dGTP is an oxidized guanine nucleotides and acts as a crucial biomarker for oxidative stress.
Product Specifications
CAS Number
[139307-94-1]
Product Name Alternative
8-Oxo-Deoxyguanosine triphosphate
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O[C@H]1C[C@H](N2C(N=C(N)NC3=O)=C3N=C2O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Molecular Formula
C10H16N5O14P3
Molecular Weight
523.18
References & Citations
[1]Patil AG, Sang PB, Govindan A, Varshney U. Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance. J Biol Chem. 2013 Apr 19;288 (16) :11252-62. doi: 10.1074/jbc.M112.442566. Epub 2013 Mar 5. PMID: 23463507; PMCID: PMC3630869.|[2]Li Y, Wang X. The role of DNA and RNA guanosine oxidation in cardiovascular diseases. Pharmacol Res. 2024 Jun;204:107187. doi: 10.1016/j.phrs.2024.107187. Epub 2024 Apr 23. PMID: 38657843.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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