ICSN3250 (hydrochloride)
ICSN3250 hydrochloride is a halitulin analogue and a mTORC1 inhibitor. ICSN3250 hydrochloride directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 hydrochloride shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 hydrochloride specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 hydrochloride can be used for the study of cancer [1].
Product Specifications
CAS Number
[1561902-79-1]
UNSPSC
12352005
Target
Atg8/LC3; Autophagy; mTOR; p62; Ribosomal S6 Kinase (RSK)
Related Pathways
Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC1=CC(C2=CN(C=C2C3=CC([N+]([O-])=O)=C(O)C(O)=C3)CCCN4CCCCCCCCCCCC4)=CC([N+]([O-])=O)=C1O.Cl
Molecular Formula
C31H41ClN4O8
Molecular Weight
633.13
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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