ICSN3250

ICSN3250 is a halitulin analogue and specific mTORC1 inhibitor. ICSN3250 directly binds to mTOR's FRB domain and displaces phosphatidic acid (PA), reversing mTORC1 activation. ICSN3250 shows high cytotoxicity in cancer cells (nanomolar concentration) through a caspase-independent cell death mechanism. ICSN3250 specifically inhibits the mTORC1 pathway, inducing autophagy and G0-G1 cell-cycle arrest in cancer cells. ICSN3250 can be used for the study of cancer[1].

Product Specifications

CAS Number

[1561902-73-5]

UNSPSC

12352005

Target

Atg8/LC3; Autophagy; mTOR; p62; Ribosomal S6 Kinase (RSK)

Related Pathways

Autophagy; MAPK/ERK Pathway; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

OC1=CC(C2=CN(CCCN3CCCCCCCCCCCC3)C=C2C4=CC([N+]([O-])=O)=C(O)C(O)=C4)=CC([N+]([O-])=O)=C1O

Molecular Formula

C31H40N4O8

Molecular Weight

596.67

References & Citations

[1]Nguyen TL, et al. mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells. Cancer Res. 2018 Sep 15;78 (18) :5384-5397.