(3S,4R) -ME-344
(3S,4R) -ME-344 is the (3S,4R) -enantiomer of ME-344 (HY-112749) . ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells) . ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research[1].
Product Specifications
CAS Number
[1374524-84-1]
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Purity
98.04
Smiles
CC1=C2C([C@@H](C3=CC=C(C=C3)O)[C@@H](C4=CC=C(C=C4)O)CO2)=CC=C1O
Molecular Formula
C22H20O4
Molecular Weight
348.39
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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