BMS-856

BMS-856 is a 17β-HSD3 inhibitor. BMS-856 inhibits enzymatic activity of 17β-HSD3, with IC50s of 60 and 300 nM respectively in the enzyme and whole cell assays[1].

Product Specifications

CAS Number

[863382-83-6]

UNSPSC

12352005

Target

17β-HSD

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CC=C(C(Cl)=C1)O)NC2=CC=C(C=C2C(NCCC3=C(OC)C=CC=C3)=O)OC4=CC=CC=C4

Molecular Formula

C29H25ClN2O5

Molecular Weight

516.97

References & Citations

[1]Day JM, et al. Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis. Endocr Relat Cancer. 2008 Sep;15 (3) :665-92.