SC-53228

SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis[1][2].

Product Specifications

CAS Number

[153633-01-3]

UNSPSC

12352005

Target

Leukotriene Receptor

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CCCC1=C2C(CC[C@H](O2)CCC(O)=O)=CC=C1OCCCOC3=C(C(OC)=C(C=C3)C(NC)=O)CC4CC4

Molecular Formula

C31H41NO7

Molecular Weight

539.66

References & Citations

[1]Fretland DJ, et al. Dermal inflammation in primates, mice, and guinea pigs: attenuation by second-generation leukotriene B4 receptor antagonist, SC-53228. Inflammation. 1995 Jun;19 (3) :333-46. |[2]Fretland D, et al. Oral efficacy of a leukotriene B4 receptor antagonist in colitic cotton-top tamarins. Gut. 1995 Nov;37 (5) :702-7.