N1-Methylpseudouridine-5′-triphosphate (tetralithium)

N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) tetralithium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability[1].

Product Specifications

Product Name Alternative

1-Methylpseudouridine-5′-triphosphate (tetralithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(C)C2=O)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O

Molecular Formula

C10H13Li4N2O15P3

Molecular Weight

521.90

References & Citations

[1]Andries O, Mc Cafferty S, De Smedt SC, Weiss R, Sanders NN, Kitada T. N (1) -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. J Control Release. 2015;217:337-344.