TRR469
TRR469 is a positive allosteric modulator of the A1 adenosine receptor (A1AR) . TRR469 significantly increases the affinity of 2-chloro N (6) -cyclopentyladenosine (CCPA) for A₁AR, increasing the number of receptors recognized by the agonist radioligand [³H]-CCPA. TRR469 shows significant effects in both anxiety and pain models. TRR469 can be used to study anxiety disorders and pain management[1][2].
Product Specifications
CAS Number
[1394867-58-3]
UNSPSC
12352005
Target
Adenosine Receptor
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
O=C(C1=C(N)SC(C2=CC=C(F)C=C2)=C1CN3CCN(C4=CC=CC=C4)CC3)C5=CC=C(Cl)C=C5
Molecular Formula
C28H25ClFN3OS
Molecular Weight
506.03
References & Citations
[1]Vincenzi F, et al. TRR469, a potent A (1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. Neuropharmacology. 2014 Jun;81:6-14. |[2]Vincenzi F, et al. Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety. Neuropharmacology. 2016 Dec;111:283-292.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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