(E/Z) -Chk2-IN-1

(E/Z) -Chk2-IN-1 ((E/Z) -Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z) -Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βII) with IC50 values both >89 nM. (E/Z) -Chk2-IN-1 can be used for the research of cancer[1].

Product Specifications

CAS Number

[693222-51-4]

Product Name Alternative

(E/Z) -Hymenialdisine analogue-1

UNSPSC

12352005

Target

Casein Kinase; Checkpoint Kinase (Chk) ; MEK; PKC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

O=C1N=C(N/C1=C2C3=C(C(NCC\2)=O)NC4=C3C=CC=C4)N

Molecular Formula

C15H13N5O2

Molecular Weight

295.30

References & Citations

[1]Sharma V, et al. Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine[J]. Bioorganic & medicinal chemistry letters, 2004, 14 (16) : 4319-4321.