TrkA Inhibitor

TrkA Inhibitor (Compound 18) is a CDK2 inhibitor with an IC50 of 0.69 μM over CDK1. TrkA Inhibitor can be used for chemotherapy-induced alopecia research[1].

Product Specifications

CAS Number

[388626-12-8]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=S(C1=CC=C(N/C=C2C(NC3=C\2C=CC=C3)=O)C=C1)(N)=O

Molecular Formula

C15H13N3O3S

Molecular Weight

315.35

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bramson HN, et al. Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2) : design, synthesis, enzymatic activities, and X-ray crystallographic analysis. J Med Chem. 2001 Dec 6;44 (25) :4339-58.