2-Cyanoethylalsterpaullone
2-Cyanoethylalsterpaullone (compound 7) is an Alsterpaullone (HY-108359) derivative, which exhibits potent and selective inhibitory activities against CDK1/Cyclin B and GSK-3β (GSK-3β: IC50=0.8 nM; CDK1/Cyclin B: IC50=0.23 nM) [1].
Product Specifications
CAS Number
[852527-97-0]
UNSPSC
12352005
Target
CDK; GSK-3
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer
Smiles
N#CCCC1=CC=C(NC(CC2=C3NC4=C2C=C([N+]([O-])=O)C=C4)=O)C3=C1
Molecular Formula
C19H14N4O3
Molecular Weight
346.34
References & Citations
[1]Kunick, et al. "Structure‐aided optimization of kinase inhibitors derived from alsterpaullone." ChemBioChem 6.3 (2005) : 541-549.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; GSK-3β
Curated Selection
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