Isogranulatimide
Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response[1][2].
Product Specifications
CAS Number
244148-46-7
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=C2C3=NC=CN3C(N4)=C1C5=C4C=CC=C5)NC2=O
Molecular Formula
C15H8N4O2
Molecular Weight
276.25
References & Citations
[1]Jiang X, et al. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Mol Cancer Ther. 2004 Oct;3 (10) :1221-7.|[2]Lavrard H, et al. Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide. ChemMedChem. 2015 Apr;10 (4) :607-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1
Frequently Asked Questions
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