Isogranulatimide

Isogranulatimide is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 value of 0.1 μM. Isogranulatimide inhibits the G2/M checkpoint and inhibits the growth of p53-mutant tumor cells. Isogranulatimide is promising for research of tumors associated with DNA damage response[1][2].

Product Specifications

CAS Number

[244148-46-7]

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(C1=C2C3=NC=CN3C(N4)=C1C5=C4C=CC=C5)NC2=O

Molecular Formula

C15H8N4O2

Molecular Weight

276.25

References & Citations

[1]Jiang X, et al. Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. Mol Cancer Ther. 2004 Oct;3 (10) :1221-7.|[2]Lavrard H, et al. Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide. ChemMedChem. 2015 Apr;10 (4) :607-9.