(S, S, S) -AHPC-Me

(S, S, S) -AHPC-Me is an E3 ligase ligand. (S, S, S) -AHPC-Me can be used for synthesis of PROTAC (4S) -PROTAC SOS1 degrader-1 diTFA (HY-144657A) [1].

Product Specifications

CAS Number

[2380273-25-4]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

NC(C(N1C[C@@H](C[C@@H]1C(N[C@@H](C2=CC=C(C=C2)C3=C(N=CS3)C)C)=O)O)=O)C(C)(C)C

Molecular Formula

C23H32N4O3S

Molecular Weight

444.59

References & Citations

[1]Zhou C, et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022; 65 (5) :3923-3942.