DM-NOFD

DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF) [1][2].

Product Specifications

CAS Number

[865488-53-5]

UNSPSC

12352005

Hazard Statement

H302-H372-H411

Target

HIF/HIF Prolyl-Hydroxylase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O

Molecular Formula

C13H15NO5

Molecular Weight

265.26

Precautions

P260-P264-P273-P391-P501

References & Citations

[1]Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20 (18) :1812-1827.|[2]Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14 (43) :12098-12120.