DM-NOFD
DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF) [1][2].
Product Specifications
CAS Number
[865488-53-5]
UNSPSC
12352005
Hazard Statement
H302-H372-H411
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O
Molecular Formula
C13H15NO5
Molecular Weight
265.26
Precautions
P260-P264-P273-P391-P501
References & Citations
[1]Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20 (18) :1812-1827.|[2]Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14 (43) :12098-12120.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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