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8-OH-DPAT (Standard)

8-OH-DPAT (Standard) is the analytical standard of 8-OH-DPAT. This product is intended for research and analytical applications. 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5) .

Product Specifications

CAS Number

78950-78-4

UNSPSC

12352100

Target

5-HT Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC1=C2CC(N(CCC)CCC)CCC2=CC=C1

Molecular Formula

C16H25NO

Molecular Weight

247.38

References & Citations

[1]DEREK N. MIDDLEMISS, et al. 8-HYDROXY-2- (DI-n-PROPYLAMINO) -TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF|[2]Bard JA, et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268 (31) :23422-6.|[3]Mori T, et al. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology (Berl) . 2016 Jun;233 (12) :2343-53.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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