KHS108-MV1

KHS108-MV1 is a conjugate of KHS108 and MV1. KHS108 is a ligand for TACC3. MV1 is an IAP antagonist that binds to cIAP1, cIAP2, and XIAP. KHS108-MV1 can be used in the research of breast cancer and fibrosarcoma[1].

Product Specifications

UNSPSC

12352005

Target

IAP; SNIPERs

Related Pathways

Apoptosis; PROTAC

Field of Research

Cancer

Smiles

O=C(NCCOCCOCCNC([C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H]3N(C([C@@H](NC([C@H](C)NC)=O)C4CCCCC4)=O)CCC3)=O)=O)C5=CC=C(C6=NC(CNC7=NC=CC(NCC(C)C)=N7)=CS6)C=C5

Molecular Formula

C57H75N11O7S

Molecular Weight

1058.34

References & Citations

[1]Ohoka N, et al. SNIPER (TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci. 2017 May;108 (5) :1032-1041.