1,2,3,6-Tetragalloylglucose

1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with Ki of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease[1][2][3].

Product Specifications

CAS Number

[79886-50-3]

Product Name Alternative

TeGG

UNSPSC

12352005

Target

UGT

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Purity

99.08

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]2[C@H]([C@@H]([C@@H](COC(C3=CC(O)=C(O)C(O)=C3)=O)O[C@H]2OC(C4=CC(O)=C(O)C(O)=C4)=O)O)OC(C5=CC(O)=C(O)C(O)=C5)=O

Molecular Formula

C34H28O22

Molecular Weight

788.57

References & Citations

[1]Park JB, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018 Oct;120:651-661.|[2]Min Byung-Sun, et al. Apoptosis-inducing activity of galloylglucoses from Juglans mandshurica in human promyeloid leukemic HL-60 cells. Natural Product Sciences 10.1 (2004) : 48-53.|[3]Zhang J, et al. Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose. Pharm Res. 2009 Sep;26 (9) :2066-80.