AZD-7648 (GMP)
AZD-7648 (GMP) is AZD-7648 (HY-111783) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity[1].
Product Specifications
CAS Number
[2230820-11-6]
UNSPSC
12352005
Target
Apoptosis; ATM/ATR; DNA-PK; PI3K
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CC1=CC2=NC=NN2C=C1NC3=NC=C(N(C)C(N4C5CCOCC5)=O)C4=N3
Molecular Formula
C18H20N8O2
Molecular Weight
380.40
References & Citations
[1]Fok JHL, et al. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10 (1) :5065.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
Phase 2
Isoform
ATM; PI3Kγ
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