SKA-31 (Standard)
SKA-31 (Standard) is the analytical standard of SKA-31. This product is intended for research and analytical applications. SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure[1].
Product Specifications
CAS Number
40172-65-4
UNSPSC
12352100
Target
Potassium Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
NC1=NC2=C3C=CC=CC3=CC=C2S1
Molecular Formula
C11H8N2S
Molecular Weight
200.27
References & Citations
[1]Sankaranarayanan A, et al. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75 (2) :281-95.|[2]Serena Pillozzi, et al. The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome CDDP resistance in colorectal cancer cells. Br J Cancer. 2018 Jan; 118 (2) : 200–212.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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