Tacrine (Standard)
Tacrine (Standard) is the analytical standard of Tacrine. This product is intended for research and analytical applications. Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease[1][2][3][4].
Product Specifications
CAS Number
321-64-2
UNSPSC
12352100
Target
Cholinesterase (ChE) ; Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
NC1=C2CCCCC2=NC3=CC=CC=C31
Molecular Formula
C13H14N2
Molecular Weight
198.27
References & Citations
[1]Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9 (4) :332-335.|[2]Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7 (23) :20321-20331. Published 2022 Jun 2.|[3]Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23 (7) :1916-1922.|[4]C Scali, et al. Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats. Pharmacol Res. 1997 Dec;36 (6) :463-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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